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Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling

Aging is an independent risk factor for CKD, but the molecular mechanisms that link aging and CKD are not well understood. The antiaging protein Klotho may be an endogenous antagonist of Wnt/β-catenin signaling, which promotes fibrogenesis, suggesting that loss of Klotho may contribute to CKD throug...

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Bibliografski detalji
Glavni autori: Zhou, Lili, Li, Yingjian, Zhou, Dong, Tan, Roderick J., Liu, Youhua
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636797/
https://ncbi.nlm.nih.gov/pubmed/23559584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012080865
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