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Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling
Aging is an independent risk factor for CKD, but the molecular mechanisms that link aging and CKD are not well understood. The antiaging protein Klotho may be an endogenous antagonist of Wnt/β-catenin signaling, which promotes fibrogenesis, suggesting that loss of Klotho may contribute to CKD throug...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Nephrology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3636797/ https://ncbi.nlm.nih.gov/pubmed/23559584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012080865 |
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