Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

We describe studies of gene transfer and expression of the human glucocerebrosidase cDNA by a Moloney murine leukemia virus (MoMuLV)-based retroviral vector in a murine gene transfer/bone marrow transplant (BMT) model. Pluripotent hematopoietic stem cells (HSCs) were assayed as the colony-forming un...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Challita, P M, Kohn, D B
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1994
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43410/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8146155/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.7.2567
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