Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.
We describe studies of gene transfer and expression of the human glucocerebrosidase cDNA by a Moloney murine leukemia virus (MoMuLV)-based retroviral vector in a murine gene transfer/bone marrow transplant (BMT) model. Pluripotent hematopoietic stem cells (HSCs) were assayed as the colony-forming un...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43410/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8146155/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.7.2567 |
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