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Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

We describe studies of gene transfer and expression of the human glucocerebrosidase cDNA by a Moloney murine leukemia virus (MoMuLV)-based retroviral vector in a murine gene transfer/bone marrow transplant (BMT) model. Pluripotent hematopoietic stem cells (HSCs) were assayed as the colony-forming un...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Challita, P M, Kohn, D B
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43410/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8146155/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.7.2567
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