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Anti-Apoptotic NF-κB and “Gain of Function” mutp53 in Concert Act Pro-Apoptotic in Response to UVB+IL-1 via Enhanced TNF Production

In response to genotoxic stress, including UVB radiation, transcription factors NF-κB and p53 inevitably influence the cellular fate. Loss of p53 function has been attributed to malignant transformation and interferes with therapeutic interventions, whereas “gain of function” mutants even enhance tu...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Müller, Ines, Beissert, Stefan, Kulms, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340977/
https://ncbi.nlm.nih.gov/pubmed/25380350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.481
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