Anti-Apoptotic NF-κB and “Gain of Function” mutp53 in Concert Act Pro-Apoptotic in Response to UVB+IL-1 via Enhanced TNF Production

In response to genotoxic stress, including UVB radiation, transcription factors NF-κB and p53 inevitably influence the cellular fate. Loss of p53 function has been attributed to malignant transformation and interferes with therapeutic interventions, whereas “gain of function” mutants even enhance tu...

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Vydáno v:J Invest Dermatol
Hlavní autoři: Müller, Ines, Beissert, Stefan, Kulms, Dagmar
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340977/
https://ncbi.nlm.nih.gov/pubmed/25380350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.481
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