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Addressing Reported Pro-Apoptotic Functions of NF-κB: Targeted Inhibition of Canonical NF-κB Enhances the Apoptotic Effects of Doxorubicin

The ability of the transcription factor NF-κB to upregulate anti-apoptotic proteins has been linked to the chemoresistance of solid tumors to standard chemotherapy. In contrast, recent studies have proposed that, in response to doxorubicin, NF-κB can be pro-apoptotic through repression of anti-apopt...

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Bibliografiska uppgifter
Huvudupphovsmän: Bednarski, Brian K., Baldwin, Albert S., Kim, Hong Jin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734988/
https://ncbi.nlm.nih.gov/pubmed/19746155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006992
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