Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

Brain-derived neurotrophic factor (BDNF) plays a crucial role in modulating neural and behavioral plasticity to drugs of abuse. Here, we demonstrate a persistent down-regulation of exon-specific Bdnf expression in the ventral tegmental area (VTA) in response to chronic opiate exposure, which is medi...

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Detaylı Bibliyografya
Yayımlandı:Nat Neurosci
Asıl Yazarlar: Koo, Ja Wook, Mazei-Robison, Michelle S., LaPlant, Quincey, Egervari, Gabor, Braunscheidel, Kevin M., Adank, Danielle N., Ferguson, Deveroux, Feng, Jian, Sun, Haosheng, Scobie, Kimberly N., Damez-Werno, Diane M., Ribeiro, Efrain, Peña, Catherine Jensen, Walker, Deena, Bagot, Rosemary C., Cahill, Michael E., Anderson, Sarah Ann R., Labonté, Benoit, Hodes, Georgia E., Browne, Heidi, Chadwick, Benjamin, Robison, Alfred J., Vialou, Vincent F., Dias, Caroline, Lorsch, Zachary, Mouzon, Ezekiell, Lobo, Mary Kay, Dietz, David M., Russo, Scott J., Neve, Rachael L., Hurd, Yasmin L., Nestler, Eric J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340719/
https://ncbi.nlm.nih.gov/pubmed/25643298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3932
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