Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

Brain-derived neurotrophic factor (BDNF) plays a crucial role in modulating neural and behavioral plasticity to drugs of abuse. Here, we demonstrate a persistent down-regulation of exon-specific Bdnf expression in the ventral tegmental area (VTA) in response to chronic opiate exposure, which is medi...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Koo, Ja Wook, Mazei-Robison, Michelle S., LaPlant, Quincey, Egervari, Gabor, Braunscheidel, Kevin M., Adank, Danielle N., Ferguson, Deveroux, Feng, Jian, Sun, Haosheng, Scobie, Kimberly N., Damez-Werno, Diane M., Ribeiro, Efrain, Peña, Catherine Jensen, Walker, Deena, Bagot, Rosemary C., Cahill, Michael E., Anderson, Sarah Ann R., Labonté, Benoit, Hodes, Georgia E., Browne, Heidi, Chadwick, Benjamin, Robison, Alfred J., Vialou, Vincent F., Dias, Caroline, Lorsch, Zachary, Mouzon, Ezekiell, Lobo, Mary Kay, Dietz, David M., Russo, Scott J., Neve, Rachael L., Hurd, Yasmin L., Nestler, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340719/
https://ncbi.nlm.nih.gov/pubmed/25643298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3932
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