Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

Brain-derived neurotrophic factor (BDNF) plays a crucial role in modulating neural and behavioral plasticity to drugs of abuse. Here, we demonstrate a persistent down-regulation of exon-specific Bdnf expression in the ventral tegmental area (VTA) in response to chronic opiate exposure, which is medi...

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發表在:Nat Neurosci
Main Authors: Koo, Ja Wook, Mazei-Robison, Michelle S., LaPlant, Quincey, Egervari, Gabor, Braunscheidel, Kevin M., Adank, Danielle N., Ferguson, Deveroux, Feng, Jian, Sun, Haosheng, Scobie, Kimberly N., Damez-Werno, Diane M., Ribeiro, Efrain, Peña, Catherine Jensen, Walker, Deena, Bagot, Rosemary C., Cahill, Michael E., Anderson, Sarah Ann R., Labonté, Benoit, Hodes, Georgia E., Browne, Heidi, Chadwick, Benjamin, Robison, Alfred J., Vialou, Vincent F., Dias, Caroline, Lorsch, Zachary, Mouzon, Ezekiell, Lobo, Mary Kay, Dietz, David M., Russo, Scott J., Neve, Rachael L., Hurd, Yasmin L., Nestler, Eric J.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340719/
https://ncbi.nlm.nih.gov/pubmed/25643298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3932
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