Serum Response Factor and cAMP Response Element Binding Protein Are Both Required for Cocaine Induction of ΔFosB

The molecular mechanism underlying induction by cocaine of ΔFosB, a transcription factor important for addiction, remains unknown. Here, we demonstrate a necessary role for two transcription factors, cAMP response element binding protein (CREB) and serum response factor (SRF), in mediating this indu...

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Main Authors: Vialou, Vincent, Feng, Jian, Robison, Alfred J., Ku, Stacy M., Ferguson, Deveroux, Scobie, Kimberly N., Mazei-Robison, Michelle S., Mouzon, Ezekiell, Nestler, Eric J.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370956/
https://ncbi.nlm.nih.gov/pubmed/22649236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1381-12.2012
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