Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

At hippocampal synapses, activation of group I metabotropic glutamate receptors (mGluRs) induces long-term depression (LTD), which requires new protein synthesis. However, the underlying mechanism remains elusive. Here we describe the translational program that underlies mGluR-LTD and identify the t...

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Pubblicato in:Nat Neurosci
Autori principali: Viana Di Prisco, Gonzalo, Huang, Wei, Buffington, Shelly A, Hsu, Chih-Chun, Bonnen, Penelope E, Placzek, Andon N, Sidrauski, Carmela, Krnjević, Krešimir, Kaufman, Randal J, Walter, Peter, Costa-Mattioli, Mauro
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340591/
https://ncbi.nlm.nih.gov/pubmed/24974795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3754
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