Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

Adolescents are especially prone to drug addiction, but the underlying biological basis of their increased vulnerability remains unknown. We reveal that translational control by phosphorylation of the translation initiation factor eIF2α (p-eIF2α) accounts for adolescent hypersensitivity to cocaine....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Huang, Wei, Placzek, Andon N, Viana Di Prisco, Gonzalo, Khatiwada, Sanjeev, Sidrauski, Carmela, Krnjević, Krešimir, Walter, Peter, Dani, John A, Costa-Mattioli, Mauro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2016
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786430/
https://ncbi.nlm.nih.gov/pubmed/26928234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12052
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