Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation. Enhanced NO production increases the activities of the transcription factors p53 and nuclear factor κB (NF-κB) in several...

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Détails bibliographiques
Publié dans:Sci Signal
Auteurs principaux: Shinozaki, Shohei, Chang, Kyungho, Sakai, Michihiro, Shimizu, Nobuyuki, Yamada, Marina, Tanaka, Tomokazu, Nakazawa, Harumasa, Ichinose, Fumito, Yamada, Yoshitsugu, Ishigami, Akihito, Ito, Hideki, Ouchi, Yasuyoshi, Starr, Marlene E., Saito, Hiroshi, Shimokado, Kentaro, Stamler, Jonathan S., Kaneki, Masao
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340581/
https://ncbi.nlm.nih.gov/pubmed/25389371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005375
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