Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation. Enhanced NO production increases the activities of the transcription factors p53 and nuclear factor κB (NF-κB) in several...

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Publicado no:Sci Signal
Main Authors: Shinozaki, Shohei, Chang, Kyungho, Sakai, Michihiro, Shimizu, Nobuyuki, Yamada, Marina, Tanaka, Tomokazu, Nakazawa, Harumasa, Ichinose, Fumito, Yamada, Yoshitsugu, Ishigami, Akihito, Ito, Hideki, Ouchi, Yasuyoshi, Starr, Marlene E., Saito, Hiroshi, Shimokado, Kentaro, Stamler, Jonathan S., Kaneki, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340581/
https://ncbi.nlm.nih.gov/pubmed/25389371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005375
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