Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation. Enhanced NO production increases the activities of the transcription factors p53 and nuclear factor κB (NF-κB) in several...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Signal
Hauptverfasser: Shinozaki, Shohei, Chang, Kyungho, Sakai, Michihiro, Shimizu, Nobuyuki, Yamada, Marina, Tanaka, Tomokazu, Nakazawa, Harumasa, Ichinose, Fumito, Yamada, Yoshitsugu, Ishigami, Akihito, Ito, Hideki, Ouchi, Yasuyoshi, Starr, Marlene E., Saito, Hiroshi, Shimokado, Kentaro, Stamler, Jonathan S., Kaneki, Masao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340581/
https://ncbi.nlm.nih.gov/pubmed/25389371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005375
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge