Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation. Enhanced NO production increases the activities of the transcription factors p53 and nuclear factor κB (NF-κB) in several...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Signal
Prif Awduron: Shinozaki, Shohei, Chang, Kyungho, Sakai, Michihiro, Shimizu, Nobuyuki, Yamada, Marina, Tanaka, Tomokazu, Nakazawa, Harumasa, Ichinose, Fumito, Yamada, Yoshitsugu, Ishigami, Akihito, Ito, Hideki, Ouchi, Yasuyoshi, Starr, Marlene E., Saito, Hiroshi, Shimokado, Kentaro, Stamler, Jonathan S., Kaneki, Masao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340581/
https://ncbi.nlm.nih.gov/pubmed/25389371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005375
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