Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

BACKGROUND: Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in pancreatic cancer models in vitro and in vivo. METHODS: Human (L3.6pl, BxP3, HPA...

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Bibliografische gegevens
Gepubliceerd in:BMC Cancer
Hoofdauteurs: Brandes, Franziska, Schmidt, Katharina, Wagner, Christine, Redekopf, Julia, Schlitt, Hans Jürgen, Geissler, Edward Kenneth, Lang, Sven Arke
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340491/
https://ncbi.nlm.nih.gov/pubmed/25884642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1064-9
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