Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

BACKGROUND: Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in pancreatic cancer models in vitro and in vivo. METHODS: Human (L3.6pl, BxP3, HPA...

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Brandes, Franziska, Schmidt, Katharina, Wagner, Christine, Redekopf, Julia, Schlitt, Hans Jürgen, Geissler, Edward Kenneth, Lang, Sven Arke
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340491/
https://ncbi.nlm.nih.gov/pubmed/25884642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1064-9
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