Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

BACKGROUND: Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in pancreatic cancer models in vitro and in vivo. METHODS: Human (L3.6pl, BxP3, HPA...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Brandes, Franziska, Schmidt, Katharina, Wagner, Christine, Redekopf, Julia, Schlitt, Hans Jürgen, Geissler, Edward Kenneth, Lang, Sven Arke
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340491/
https://ncbi.nlm.nih.gov/pubmed/25884642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1064-9
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