Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

[Image: see text] Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued by exogenous serine, suggesting p...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Fan, Jing, Teng, Xin, Liu, Ling, Mattaini, Katherine R., Looper, Ryan E., Vander Heiden, Matthew G., Rabinowitz, Joshua D.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340346/
https://ncbi.nlm.nih.gov/pubmed/25406093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500683c
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