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Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis
Metabolomics is a valuable tool for studying tissue- and organism-specific metabolism. In normal mouse testis, we found 70 μM S-2-hydroxyglutarate (2HG), more than 10-fold greater than in other tissues. S-2HG is a competitive inhibitor of α-ketoglutarate-dependent demethylation enzymes and can alter...
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| Udgivet i: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5317044/ https://ncbi.nlm.nih.gov/pubmed/27333189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00290 |
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