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SILENCING GASTRIN-RELEASING PEPTIDE RECEPTOR SUPPRESSES KEY REGULATORS OF AEROBIC GLYCOLYSIS IN NEUROBLASTOMA CELLS
BACKGROUND: Under normoxic conditions, cancer cells use aerobic glycolysis as opposed to glucose oxidation for energy production; this altered metabolism correlates with poor outcomes in neuroblastoma. Hypoxia-inducible factor-1α (HIF-1α) and pyruvate dehydrogenase kinase 4 (PDK4) regulate aerobic g...
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| Izdano u: | Pediatr Blood Cancer |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4339541/ https://ncbi.nlm.nih.gov/pubmed/25630799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25348 |
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