FX11 INHIBITS AEROBIC GLYCOLYSIS AND GROWTH OF NEUROBLASTOMA CELLS

BACKGROUND: The MYC family promotes neuroblastoma tumorigenesis at least in part through the induction of aerobic glycolysis by promoting the transcription of key glycolytic enzymes, such as LDHA. FX11 is a selective inhibitor of LDHA that has demonstrated preclinical efficacy in adult cancers. Here...

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Publicat a:Surgery
Autors principals: Rellinger, Eric J., Craig, Brian T., Alvarez, Alexandra L., Dusek, Haley L., Kim, Kwang W., Qiao, Jingbo, Chung, Dai H.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369647/
https://ncbi.nlm.nih.gov/pubmed/27919448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2016.09.009
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