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BET INHIBITION BLOCKS TUMOR PROGRESSION AND PROMOTES DIFFERENTIATION IN NEUROBLASTOMA
BACKGROUND: MYCN amplification is a key molecular hallmark of high-risk neuroblastoma. Previously considered an “undruggable” target, MYCN transcription can be disrupted by inhibiting the bromodomain and extraterminal (BET) domain family of proteins that epigenetically regulates MYCN transcription....
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| 出版年: | Surgery |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536146/ https://ncbi.nlm.nih.gov/pubmed/26067464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2015.04.017 |
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