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BET INHIBITION BLOCKS TUMOR PROGRESSION AND PROMOTES DIFFERENTIATION IN NEUROBLASTOMA
BACKGROUND: MYCN amplification is a key molecular hallmark of high-risk neuroblastoma. Previously considered an “undruggable” target, MYCN transcription can be disrupted by inhibiting the bromodomain and extraterminal (BET) domain family of proteins that epigenetically regulates MYCN transcription....
Tallennettuna:
| Julkaisussa: | Surgery |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536146/ https://ncbi.nlm.nih.gov/pubmed/26067464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2015.04.017 |
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