BET INHIBITION BLOCKS TUMOR PROGRESSION AND PROMOTES DIFFERENTIATION IN NEUROBLASTOMA

BACKGROUND: MYCN amplification is a key molecular hallmark of high-risk neuroblastoma. Previously considered an “undruggable” target, MYCN transcription can be disrupted by inhibiting the bromodomain and extraterminal (BET) domain family of proteins that epigenetically regulates MYCN transcription....

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Surgery
Autors principals: Lee, Sora, Rellinger, Eric J., Kim, Kwang Woon, Craig, Brian T., Romain, Carmelle V., Qiao, Jingbo, Chung, Dai H.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536146/
https://ncbi.nlm.nih.gov/pubmed/26067464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2015.04.017
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars