BET INHIBITION BLOCKS TUMOR PROGRESSION AND PROMOTES DIFFERENTIATION IN NEUROBLASTOMA

BACKGROUND: MYCN amplification is a key molecular hallmark of high-risk neuroblastoma. Previously considered an “undruggable” target, MYCN transcription can be disrupted by inhibiting the bromodomain and extraterminal (BET) domain family of proteins that epigenetically regulates MYCN transcription....

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Gepubliceerd in:Surgery
Hoofdauteurs: Lee, Sora, Rellinger, Eric J., Kim, Kwang Woon, Craig, Brian T., Romain, Carmelle V., Qiao, Jingbo, Chung, Dai H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536146/
https://ncbi.nlm.nih.gov/pubmed/26067464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2015.04.017
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