SILENCING GASTRIN-RELEASING PEPTIDE RECEPTOR SUPPRESSES KEY REGULATORS OF AEROBIC GLYCOLYSIS IN NEUROBLASTOMA CELLS

BACKGROUND: Under normoxic conditions, cancer cells use aerobic glycolysis as opposed to glucose oxidation for energy production; this altered metabolism correlates with poor outcomes in neuroblastoma. Hypoxia-inducible factor-1α (HIF-1α) and pyruvate dehydrogenase kinase 4 (PDK4) regulate aerobic g...

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I publikationen:Pediatr Blood Cancer
Huvudupphovsmän: Rellinger, Eric J., Romain, Carmelle, Choi, SunPhil, Qiao, Jingbo, Chung, Dai H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339541/
https://ncbi.nlm.nih.gov/pubmed/25630799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25348
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