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Identification of STAT1 and STAT3 Specific Inhibitors Using Comparative Virtual Screening and Docking Validation

Signal transducers and activators of transcription (STATs) facilitate action of cytokines, growth factors and pathogens. STAT activation is mediated by a highly conserved SH2 domain, which interacts with phosphotyrosine motifs for specific STAT-receptor contacts and STAT dimerization. The active dim...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Szelag, Malgorzata, Czerwoniec, Anna, Wesoly, Joanna, Bluyssen, Hans A. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339377/
https://ncbi.nlm.nih.gov/pubmed/25710482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116688
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