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Identification of novel PTPRQ phosphatase inhibitors based on the virtual screening with docking simulations
Protein tyrosine phosphatase receptor type Q (PTPRQ) is an unusual PTP that has intrinsic dephosphorylating activity for various phosphatidyl inositides instead of phospho-tyrosine substrates. Although PTPRQ was known to be involved in the pathogenesis of obesity, no small-molecule inhibitor has bee...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3765866/ https://ncbi.nlm.nih.gov/pubmed/23981594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-10-49 |
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