Identification of a New Series of STAT3 Inhibitors by Virtual Screening

[Image: see text] The signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for oncology drug development. We identified a N-[2-(1,3,4-oxadiazolyl)]-4-quinolinecarboxamide derivative, STX-0119, as a novel STAT3 dimerization inhibitor by a vir...

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Detalhes bibliográficos
Main Authors: Matsuno, Kenji, Masuda, Yoshiaki, Uehara, Yutaka, Sato, Hiroshi, Muroya, Ayumu, Takahashi, Osamu, Yokotagawa, Takane, Furuya, Toshio, Okawara, Tadashi, Otsuka, Masami, Ogo, Naohisa, Ashizawa, Tadashi, Oshita, Chie, Tai, Sachiko, Ishii, Hidee, Akiyama, Yasuto, Asai, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007973/
https://ncbi.nlm.nih.gov/pubmed/24900220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000273
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