Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways

Prions induce lethal neurodegeneration and consist of PrP(Sc,) an aggregated conformer of the cellular prion protein PrP(C.) Antibody-derived ligands to the globular domain of PrP(C) (collectively termed GDL) are also neurotoxic. Here we show that GDL and prion infections activate the same pathways....

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Udgivet i:PLoS Pathog
Main Authors: Herrmann, Uli S., Sonati, Tiziana, Falsig, Jeppe, Reimann, Regina R., Dametto, Paolo, O’Connor, Tracy, Li, Bei, Lau, Agnes, Hornemann, Simone, Sorce, Silvia, Wagner, Uli, Sanoudou, Despina, Aguzzi, Adriano
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339193/
https://ncbi.nlm.nih.gov/pubmed/25710374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004662
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