Mitochondrial Aldehyde Dehydrogenase Activation by Alda‐1 Inhibits Atherosclerosis and Attenuates Hepatic Steatosis in Apolipoprotein E‐Knockout Mice

BACKGROUND: Mitochondrial dysfunction has been shown to play an important role in the development of atherosclerosis and nonalcoholic fatty liver disease (NAFLD). Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldehydes, is considered to exert...

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Detalles Bibliográficos
Publicado en:J Am Heart Assoc
Main Authors: Stachowicz, Aneta, Olszanecki, Rafał, Suski, Maciej, Wiśniewska, Anna, Totoń‐Żurańska, Justyna, Madej, Józef, Jawień, Jacek, Białas, Magdalena, Okoń, Krzysztof, Gajda, Mariusz, Głombik, Katarzyna, Basta‐Kaim, Agnieszka, Korbut, Ryszard
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2014
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338726/
https://ncbi.nlm.nih.gov/pubmed/25392542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001329
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