Mitochondrial Aldehyde Dehydrogenase Activation by Alda‐1 Inhibits Atherosclerosis and Attenuates Hepatic Steatosis in Apolipoprotein E‐Knockout Mice

BACKGROUND: Mitochondrial dysfunction has been shown to play an important role in the development of atherosclerosis and nonalcoholic fatty liver disease (NAFLD). Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldehydes, is considered to exert...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Heart Assoc
Auteurs principaux: Stachowicz, Aneta, Olszanecki, Rafał, Suski, Maciej, Wiśniewska, Anna, Totoń‐Żurańska, Justyna, Madej, Józef, Jawień, Jacek, Białas, Magdalena, Okoń, Krzysztof, Gajda, Mariusz, Głombik, Katarzyna, Basta‐Kaim, Agnieszka, Korbut, Ryszard
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2014
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338726/
https://ncbi.nlm.nih.gov/pubmed/25392542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001329
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