Mitochondrial Aldehyde Dehydrogenase Activation by Alda‐1 Inhibits Atherosclerosis and Attenuates Hepatic Steatosis in Apolipoprotein E‐Knockout Mice

BACKGROUND: Mitochondrial dysfunction has been shown to play an important role in the development of atherosclerosis and nonalcoholic fatty liver disease (NAFLD). Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldehydes, is considered to exert...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Heart Assoc
Prif Awduron: Stachowicz, Aneta, Olszanecki, Rafał, Suski, Maciej, Wiśniewska, Anna, Totoń‐Żurańska, Justyna, Madej, Józef, Jawień, Jacek, Białas, Magdalena, Okoń, Krzysztof, Gajda, Mariusz, Głombik, Katarzyna, Basta‐Kaim, Agnieszka, Korbut, Ryszard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Publishing Ltd 2014
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338726/
https://ncbi.nlm.nih.gov/pubmed/25392542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001329
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