Mitochondrial Aldehyde Dehydrogenase Activation by Alda‐1 Inhibits Atherosclerosis and Attenuates Hepatic Steatosis in Apolipoprotein E‐Knockout Mice

BACKGROUND: Mitochondrial dysfunction has been shown to play an important role in the development of atherosclerosis and nonalcoholic fatty liver disease (NAFLD). Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldehydes, is considered to exert...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Stachowicz, Aneta, Olszanecki, Rafał, Suski, Maciej, Wiśniewska, Anna, Totoń‐Żurańska, Justyna, Madej, Józef, Jawień, Jacek, Białas, Magdalena, Okoń, Krzysztof, Gajda, Mariusz, Głombik, Katarzyna, Basta‐Kaim, Agnieszka, Korbut, Ryszard
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338726/
https://ncbi.nlm.nih.gov/pubmed/25392542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001329
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