Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state

MeCP2 is a nuclear protein with an affinity for methylated DNA that can recruit histone deacetylases. Deficiency or excess of MeCP2 causes severe neurological problems, suggesting that the number of molecules per cell must be precisely regulated. We quantified MeCP2 in neuronal nuclei and found that...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Skene, Peter J, Illingworth, Robert S, Webb, Shaun, Kerr, Alastair, James, Keith D., Turner, Daniel J., Andrews, Rob, Bird, Adrian P
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338610/
https://ncbi.nlm.nih.gov/pubmed/20188665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.030
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