Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells

Trimethylation of histone H3 Lys 4 (H3K4me3) is a mark of active and poised promoters. The Set1 complex is responsible for most somatic H3K4me3 and contains the conserved subunit CxxC finger protein 1 (Cfp1), which binds to unmethylated CpGs and links H3K4me3 with CpG islands (CGIs). Here we report...

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Hlavní autoři: Clouaire, Thomas, Webb, Shaun, Skene, Pete, Illingworth, Robert, Kerr, Alastair, Andrews, Robert, Lee, Jeong-Heon, Skalnik, David, Bird, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2012
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418589/
https://ncbi.nlm.nih.gov/pubmed/22855832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.194209.112
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