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Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state

MeCP2 is a nuclear protein with an affinity for methylated DNA that can recruit histone deacetylases. Deficiency or excess of MeCP2 causes severe neurological problems, suggesting that the number of molecules per cell must be precisely regulated. We quantified MeCP2 in neuronal nuclei and found that...

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Dades bibliogràfiques
Publicat a:Mol Cell
Autors principals: Skene, Peter J, Illingworth, Robert S, Webb, Shaun, Kerr, Alastair, James, Keith D., Turner, Daniel J., Andrews, Rob, Bird, Adrian P
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338610/
https://ncbi.nlm.nih.gov/pubmed/20188665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.030
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