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Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state
MeCP2 is a nuclear protein with an affinity for methylated DNA that can recruit histone deacetylases. Deficiency or excess of MeCP2 causes severe neurological problems, suggesting that the number of molecules per cell must be precisely regulated. We quantified MeCP2 in neuronal nuclei and found that...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4338610/ https://ncbi.nlm.nih.gov/pubmed/20188665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.030 |
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