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Target specificity of the CRISPR-Cas9 system

The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome editing and transcriptome modulation, and has shown great promise in correcting mutations in human genetic diseases. Off-target effect...

詳細記述

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書誌詳細
出版年:Quant Biol
主要な著者: Wu, Xuebing, Kriz, Andrea J., Sharp, Phillip A.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338555/
https://ncbi.nlm.nih.gov/pubmed/25722925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40484-014-0030-x
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