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Target specificity of the CRISPR-Cas9 system
The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome editing and transcriptome modulation, and has shown great promise in correcting mutations in human genetic diseases. Off-target effect...
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| Publicado en: | Quant Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4338555/ https://ncbi.nlm.nih.gov/pubmed/25722925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40484-014-0030-x |
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