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Connections between TET proteins and aberrant DNA modification in cancer

DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer, and an imbalance in DNA methylation/demethylation cycles is intimately implicated in the onset and progression of tumors. TET (ten-eleven translocation) proteins are Fe(II) and 2-oxoglutarate dependent dioxyge...

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Detalhes bibliográficos
Publicado no:Trends Genet
Main Authors: Huang, Yun, Rao, Anjana
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337960/
https://ncbi.nlm.nih.gov/pubmed/25132561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2014.07.005
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