Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease

Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycogen synthesis in neurons must be tightly controlled, due to neuronal sensitivity to perturbations in glycogen metabolism. Lafora disease (LD) is a fatal, congenital, neurodegenerative epilepsy. Mutatio...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Raththagala, Madushi, Brewer, M. Kathryn, Parker, Matthew W., Sherwood, Amanda R., Wong, Brian K., Hsu, Simon, Bridges, Travis M., Paasch, Bradley C., Hellman, Lance M., Husodo, Satrio, Meekins, David A., Taylor, Adam O., Turner, Benjamin D., Auger, Kyle D., Dukhande, Vikas V., Chakravarthy, Srinivas, Sanz, Pascual, Woods, Virgil V., Li, Sheng, Vander Kooi, Craig W., Gentry, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337892/
https://ncbi.nlm.nih.gov/pubmed/25544560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.020
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