Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease

Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycogen synthesis in neurons must be tightly controlled, due to neuronal sensitivity to perturbations in glycogen metabolism. Lafora disease (LD) is a fatal, congenital, neurodegenerative epilepsy. Mutatio...

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Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Raththagala, Madushi, Brewer, M. Kathryn, Parker, Matthew W., Sherwood, Amanda R., Wong, Brian K., Hsu, Simon, Bridges, Travis M., Paasch, Bradley C., Hellman, Lance M., Husodo, Satrio, Meekins, David A., Taylor, Adam O., Turner, Benjamin D., Auger, Kyle D., Dukhande, Vikas V., Chakravarthy, Srinivas, Sanz, Pascual, Woods, Virgil V., Li, Sheng, Vander Kooi, Craig W., Gentry, Matthew S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337892/
https://ncbi.nlm.nih.gov/pubmed/25544560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.020
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