Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease

Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycogen synthesis in neurons must be tightly controlled, due to neuronal sensitivity to perturbations in glycogen metabolism. Lafora disease (LD) is a fatal, congenital, neurodegenerative epilepsy. Mutatio...

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書誌詳細
出版年:Mol Cell
主要な著者: Raththagala, Madushi, Brewer, M. Kathryn, Parker, Matthew W., Sherwood, Amanda R., Wong, Brian K., Hsu, Simon, Bridges, Travis M., Paasch, Bradley C., Hellman, Lance M., Husodo, Satrio, Meekins, David A., Taylor, Adam O., Turner, Benjamin D., Auger, Kyle D., Dukhande, Vikas V., Chakravarthy, Srinivas, Sanz, Pascual, Woods, Virgil V., Li, Sheng, Vander Kooi, Craig W., Gentry, Matthew S.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337892/
https://ncbi.nlm.nih.gov/pubmed/25544560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.020
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