Targeting Latent TGFβ release in muscular dystrophy

Latent TGFβ binding proteins (LTBPs) bind to inactive TGFβ in the extracellular matrix. In mice, muscular dystrophy symptoms are intensified by a genetic polymorphism that changes the hinge region of LTBP, leading to increased proteolytic susceptibility and TGFβ release. We have found that the hinge...

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Bibliografiska uppgifter
I publikationen:Sci Transl Med
Huvudupphovsmän: Ceco, Ermelinda, Bogdanovich, Sasha, Gardner, Brandon, Miller, Tamari, DeJesus, Adam, Earley, Judy U., Hadhazy, Michele, Smith, Lucas R., Barton, Elisabeth R., Molkentin, Jeffery D., McNally, Elizabeth M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337885/
https://ncbi.nlm.nih.gov/pubmed/25338755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010018
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