Targeting Latent TGFβ release in muscular dystrophy

Latent TGFβ binding proteins (LTBPs) bind to inactive TGFβ in the extracellular matrix. In mice, muscular dystrophy symptoms are intensified by a genetic polymorphism that changes the hinge region of LTBP, leading to increased proteolytic susceptibility and TGFβ release. We have found that the hinge...

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Bibliografiske detaljer
Udgivet i:Sci Transl Med
Main Authors: Ceco, Ermelinda, Bogdanovich, Sasha, Gardner, Brandon, Miller, Tamari, DeJesus, Adam, Earley, Judy U., Hadhazy, Michele, Smith, Lucas R., Barton, Elisabeth R., Molkentin, Jeffery D., McNally, Elizabeth M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337885/
https://ncbi.nlm.nih.gov/pubmed/25338755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010018
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