Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ

Latent TGFβ binding proteins (LTBPs) regulate the extracellular availability of latent TGFβ. LTBP4 was identified as a genetic modifier of muscular dystrophy in mice and humans. An in-frame insertion polymorphism in the murine Ltbp4 gene associates with partial protection against muscular dystrophy....

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Vydáno v:PLoS Genet
Hlavní autoři: Lamar, Kay-Marie, Bogdanovich, Sasha, Gardner, Brandon B., Gao, Quan Q., Miller, Tamari, Earley, Judy U., Hadhazy, Michele, Vo, Andy H., Wren, Lisa, Molkentin, Jeffery D., McNally, Elizabeth M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858180/
https://ncbi.nlm.nih.gov/pubmed/27148972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006019
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