Inhibition of H3K27me3-Specific Histone Demethylases JMJD3 and UTX Blocks Reactivation of Herpes Simplex Virus 1 in Trigeminal Ganglion Neurons

Herpes simplex virus 1 (HSV-1) genomes are associated with the repressive heterochromatic marks H3K9me2/me3 and H3K27me3 during latency. Previous studies have demonstrated that inhibitors of H3K9me2/me3 histone demethylases reduce the ability of HSV-1 to reactivate from latency. Here we demonstrate...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Messer, Harald G. P., Jacobs, Derek, Dhummakupt, Adit, Bloom, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337550/
https://ncbi.nlm.nih.gov/pubmed/25552720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03052-14
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