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Sp1 Sites in the Noncoding Control Region of BK Polyomavirus Are Key Regulators of Bidirectional Viral Early and Late Gene Expression

In kidney transplant patients with BK polyomavirus (BKPyV) nephropathy, viral variants arise bearing rearranged noncoding control regions (rr-NCCRs) that increase viral early gene expression, replicative fitness, and cytopathology. rr-NCCRs result from various deletions and duplications of archetype...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Bethge, Tobias, Hachemi, Helen A., Manzetti, Julia, Gosert, Rainer, Schaffner, Walter, Hirsch, Hans H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337534/
https://ncbi.nlm.nih.gov/pubmed/25589646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03625-14
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