Sp1 Sites in the Noncoding Control Region of BK Polyomavirus Are Key Regulators of Bidirectional Viral Early and Late Gene Expression

In kidney transplant patients with BK polyomavirus (BKPyV) nephropathy, viral variants arise bearing rearranged noncoding control regions (rr-NCCRs) that increase viral early gene expression, replicative fitness, and cytopathology. rr-NCCRs result from various deletions and duplications of archetype...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Bethge, Tobias, Hachemi, Helen A., Manzetti, Julia, Gosert, Rainer, Schaffner, Walter, Hirsch, Hans H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Genome Replication and Regulation of Viral Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337534/
https://ncbi.nlm.nih.gov/pubmed/25589646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03625-14
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