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Liposomal insulin promoter–thymidine kinase gene therapy followed by ganciclovir effectively ablates human pancreatic cancer in mice
PDX1 is overexpressed in pancreatic cancer, and activates the insulin promoter (IP). Adenoviral IP–thymidine kinase and ganciclovir (TK/GCV) suppresses human pancreatic ductal carcinoma (PDAC) in mice, but repeated doses carry significant toxicity. We hypothesized that multiple cycles of liposomal I...
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| Publicado no: | Cancer Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4336837/ https://ncbi.nlm.nih.gov/pubmed/25596375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.01.002 |
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