Thymidine Kinase Suicide Gene-mediated Ganciclovir Ablation of Autologous Gene-modified Rhesus Hematopoiesis

Despite the genotoxic complications encountered in clinical gene therapy trials for primary immunodeficiency diseases targeting hematopoietic cells with integrating vectors; this strategy holds promise for the cure of several monogenic blood, metabolic and neurodegenerative diseases. In this study,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Barese, Cecilia N, Krouse, Allen E, Metzger, Mark E, King, Connor A, Traversari, Catia, Marini, Frank C, Donahue, Robert E, Dunbar, Cynthia E
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2012
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464648/
https://ncbi.nlm.nih.gov/pubmed/22910293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.166
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